During the two days of me being sick i watched the enterity of Fullmetal alchemist brotherhood so thats about 33 or so hours out of 48.
I can relate to that, watched all of FMA and FMA: Brotherhood over the course of 3 days a couple of years back. Wasn't sick I just had a very empty life

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As for "serious, no nonsense" anime, I do not recommend Samourai Champloo, it has its way goofy moments (still very good watch so do watch it anyway)
If you do not mind gory stuff (not too much but still there) I do like Ergo Proxy and a favorite "no-one-seems-to-know-about-it" is Boogiepop Phantom. Very special stuff in the last one, it's different. There is also Chrono Crusade, but its a little weird, don't remember if there's much comedy in it....
Going to have to agree with UFO about Samurai Champloo here. It is a good show and has some very serious moments, but overall it is light hearted and has much silliness. As for Ergo Proxy, I personally think it is overrated. I never managed to actually finish the show as I just didn't find it enjoyable, the characters and story were rather bland.
Watching Angel Beats! right now. And I suppose I have some series to finish after that.
Good luck with that, only show to ever make me cry.
Also I believe some people were recommending Black Lagoon, which I would also strongly suggest watching. One of my favourite shows, and a pretty dark one too.